WILGO RESEARCH INDEX
TB-500
TB-500 is a commercial research name associated with thymosin beta-4–related material. The peer-reviewed literature is overwhelmingly about thymosin beta-4 (Tβ4), an endogenous 43-amino-acid actin-binding peptide. Because commercial TB-500 identity and formulation can vary, WILGO does not treat every Tβ4 paper as proof about every material sold under the TB-500 name.
Thymosin β4-relatedActin biologyAngiogenesisWound researchIdentity caveat
EVIDENCE MAP
What kind of evidence exists?
This page deliberately distinguishes native thymosin β4 evidence from the looser commercial label TB-500.
The naming problem is scientifically important.
Many websites collapse “TB-500” and “thymosin beta-4” into a single term. That is too loose for a research index. WILGO therefore labels the underlying literature as Tβ4 evidence and keeps the commercial-name inference explicit.
PUBLISHED LITERATURE
Selected studies.
Selected sources are grouped by study type so model limitations remain visible.
PRECLINICAL · WOUND HEALING
Thymosin beta4 accelerates wound healing
In a full-thickness rodent wound model, Tβ4 increased re-epithelialization, wound contraction, collagen deposition, and angiogenesis; it also stimulated keratinocyte migration in vitro. This is foundational preclinical wound-healing evidence for native Tβ4.
MECHANISTIC · ACTIN / ANGIOGENESIS
The actin binding site on thymosin beta4 promotes angiogenesis
Using endothelial migration and vessel-sprouting assays, the study identified the actin-binding motif of Tβ4 as essential to its angiogenic activity.
MECHANISTIC · ENDOTHELIAL
Thymosin beta4 enhances endothelial cell differentiation and angiogenesis
Exogenous Tβ4 increased endothelial tube formation and vascular sprouting in experimental systems, supporting autocrine/paracrine roles in vessel formation.
PRECLINICAL · BURN MODEL
Thymosin β4 has a major role in dermal burn wound healing that involves actin cytoskeletal remodelling via heat-shock protein 70
Cell and dermal-burn experiments linked Tβ4 with HSP70-related actin remodeling, wound closure, and vascularization. The work remains preclinical.
HUMAN / TRANSLATIONAL REVIEW
The regenerative peptide thymosin β4 accelerates the rate of dermal healing in preclinical animal models and in patients
This translational review describes animal wound models and two phase 2 clinical trials involving stasis and pressure ulcers, reporting faster healing among wounds that healed.
REVIEW · VASCULAR BIOLOGY
Thymosin β4 and the vasculature: multiple roles in development, repair and protection against disease
The review covers vasculogenesis, angiogenesis, arteriogenesis, endothelial-mesenchymal transition, extracellular-matrix remodeling, and remaining uncertainty about molecular mechanisms.
REFERENCES
Primary sources.
Direct PubMed links are used wherever possible.
Thymosin beta4 accelerates wound healing1999 · J Invest Dermatol · PMID 10469335 · DOI 10.1046/j.1523-1747.1999.00708.x · PubMed →
The actin binding site on thymosin beta4 promotes angiogenesis2003 · PMID 14500546 · PubMed →
Thymosin beta4 enhances endothelial cell differentiation and angiogenesis2003 · PMID 14517430 · PubMed →
Thymosin β4 has a major role in dermal burn wound healing that involves actin cytoskeletal remodelling via heat-shock protein 702017 · PMID 25921810 · DOI 10.1002/term.2028 · PubMed →
The regenerative peptide thymosin β4 accelerates the rate of dermal healing in preclinical animal models and in patients2012 · PMID 23050815 · DOI 10.1111/j.1749-6632.2012.06717.x · PubMed →
Thymosin β4 and the vasculature: multiple roles in development, repair and protection against disease2018 · PMID 30063849 · DOI 10.1080/14712598.2018.1459558 · PubMed →
Research-use notice: This resource summarizes published scientific literature for informational and research-reference purposes. It does not provide medical advice, dosing, reconstitution, injection, therapeutic, diagnostic, or other human-use instructions. WILGO products are intended for laboratory research use only and are not presented for human or animal consumption, diagnosis, treatment, prevention, weight management, cosmetic use, or self-administration.